Dimethyl fumarate/dimethylformamide (DMF) detection
What does DMF mean?
(DMF) is the English abbreviation of dimethyl fumarate or dimethylformamide, which are two widely restricted hazardous substances. Dimethyl Fumarate (Dimethyl Fumarate) is referred to as DMF. Molecular formula: C6H8O4, CAS No.: 624-49-7 It appears as white crystal or crystalline powder at room temperature.
N,N-Dimethylformamide; English name: Dimethylformamide; or N,N-Dimethylformamide; also referred to as DMF; CAS: 68-12-2, is a colorless, light ammonia-smelling liquid, mainly used as an industrial solvent , used in the pharmaceutical industry to produce vitamins and hormones, and also used in the manufacture of dichloramid, etc.
Dimethyl fumarate (DMF) uses
Dimethyl fumarate is usually used as moisture-proof bags to prevent corrosion and mildew in products. It is often used in the production, storage, and transportation of leather, footwear, textiles, etc.
In addition, because dimethyl fumarate has the characteristics of low toxicity, strong antibacterial ability, many antibacterial types, and is not affected by the environment, it is also widely used in food, grain, feed, cosmetics, tobacco, etc. for antiseptic, mildew, and preservation . .
Dimethyl fumarate (DMF) hazards
Dimethyl fumarate is mostly packaged in small bags fixed inside furniture or added to shoe boxes. This keeps the product dry and moisture-proof and prevents the product from growing mold. However, consumers exposed to the product were also harmed. Dimethyl fumarate penetrates consumers' skin through clothing and causes painful skin contact dermatitis, including itching, irritation, redness and burning; in some cases, acute respiratory illness has also been reported . Dermatitis is particularly difficult to treat. The presence of dimethyl fumarate therefore becomes a serious hazard.
Dimethylformamide (DMF) hazards
Dimethylformamide (DMF) is irritating to eyes, skin and respiratory tract.
After invading the body, it is mainly metabolized in the liver and excreted quickly. The main target organ is the liver, and the kidneys are also damaged to some extent. It is moderately toxic.
In addition, dimethylformamide (DMF) is also harmful to the environment, and some EU countries now have restrictions on dimethylformamide (DMF) in products.
Restrictions on dimethyl fumarate (DMF)
In early 2009, the European Commission passed the "Draft requiring member states to ensure that products containing the biocide DMF dimethyl fumarate are not placed on the market or sold" ( 2009/251/EC ), stipulating that by May 2009 After March 1 , products containing DMF dimethyl fumarate are prohibited from being put on the market or sold on the market. Requirements for restricting the use of DMF (dimethyl fumarate) 1. It is stipulated that after May 1 , 2009 , products containing DMF dimethyl fumarate are prohibited from being put on the market or sold on the market, and have been put on the market or sold on the market . Products containing DMF dimethyl fumarate should be recalled . 2. The content of DMF dimethyl fumarate in products or product parts should not exceed 0.1 mg/kg ( 0.1ppm )
3. Desiccant and antifungal bags containing DMF dimethyl fumarate are not allowed to be used in the product and packaging .
2012年5月16日，欧盟公报发布了条例(EU) No 412/2012, 将富马酸二甲酯加入REACH法规附件17 (对某些危险物质、混合物、物品在制造，投放市场和使用过程中的限制)物质清单第61项，法令在自欧盟公报发布之日20天后执行，并要求成员国将其无条件转化为本国法律。这预示着2012年6月4日起，全欧盟将限制DMF富马酸二甲酯。
根据此次修订，用于物品及物品的任一成分中的富马酸二甲酯含量不得超过0.1mg/kg，任何含有DMF含量超过0.1mg/kg的物品或任何部件禁止投放市场。
限制规定出台背景
富马酸二甲酯(DMF)是上世纪80年代国际上兴起的高效、低毒防霉剂，在我国家具业、制鞋业广泛运用，超过正常使用量时可能引起消费者皮肤过敏、皮疹或灼伤，去年法国、波兰、芬兰、瑞典和英国等国相继发生消费者过敏事件。2009/251/EC公布后，对富马酸二甲酯的禁令从法国、西班牙、比利时3国扩展到整个欧盟，此规定将成为制约我国鞋类、箱包、沙发等皮具加工出口企业提出又一技术要求。
Commonly related testing standards and methods for DMF dimethyl fumarate:
DMF test method for EU REACH regulations : solvent extraction, gas chromatography - mass spectrometry ( GC-MS ) method.
GB/T 27717-2011 Determination of dimethyl fumarate content in national standard furniture.
DB43/T 353-2007 Determination of dimethyl fumarate in Hunan local standard food by gas chromatography.
SN/T 2454-2010 Determination of dimethyl fumarate in antifungal agents by gas chromatography.
SN/T 2450-2010 Determination of dimethyl fumarate in textiles by gas chromatography - mass spectrometry.
SN/T 2446-2010 Determination of dimethyl fumarate in leather and its products by gas chromatography / mass spectrometry.
GB/T 26702-2011 National standard chemical test for leather and fur - Determination of dimethyl fumarate content.
GB/T 26713-2011 National standard footwear chemical test method Determination of dimethyl fumarate (DMF) .
GB/T 27730-2011 National standard for determination of dimethyl fumarate content in toy products by gas chromatography - mass spectrometry ( GC-MS ) method.